As a medication, it is used to treat a number of conditions, including anaphylaxis, cardiac arrest, asthma, and superficial bleeding. The pH range is 2.2-5.0. Patient Body Weight, 5.3 Serious Infections at the Injection Site, 5.4 Allergic Reactions Associated with Sulfite, 13.1 Carcinogenesis, Mutagenesis, Impairment of Fertility, Report Adverse Only a healthcare provider should give additional doses of epinephrine if you need more than 2 injections for a single anaphylaxis episode. For Adult. Read this Patient Information leaflet carefully before you use epinephrine injection, and each time you get a refill. When your sharps disposal container is almost full, you will need to follow your community guidelines for the right way to dispose of your sharps disposal container. Ask your healthcare provider to show you how to properly hold the leg of a young child during an injection. To view updated drug label links, paste the RSS feed address (URL) shown below into a RSS reader, or use a browser which supports RSS feeds, such as Safari for Mac OS X. Pediatrics 2010;126(5):e1400-13. Do not remove the blue end caps until you are ready to use epinephrine injection. Epinephrine injection is a disposable, prefilled automatic injection device (auto-injector) used to treat life-threatening, allergic emergencies including anaphylaxis in people who are at risk for or have a history of serious allergic emergencies. Rarely, people who use epinephrine injection may develop infections at the injection site within a few days of an injection. Especially tell your healthcare provider if you take certain asthma medicines. If the carrying case or epinephrine injection is dropped, check for damage and leakage. Long-term studies to evaluate the carcinogenic potential of epinephrine have not been conducted. Never inject into any other part of the body. When given intramuscularly or subcutaneously, epinephrine has a rapid onset and short duration of action. Thoroughly review the patient instructions and operation of epinephrine injection, USP with patients and caregivers prior to use [see Patient Counseling Information (17)]. Tell the healthcare provider where on your body you received the accidental injection. Since the dose of epinephrine delivered from epinephrine injection is fixed, consider using other forms of injectable epinephrine if doses lower than 0.15 mg are deemed necessary. Rare cases of stress cardiomyopathy have been reported in patients treated with epinephrine. It is not known if epinephrine passes into your breast milk. Before you need to use your epinephrine injection, make sure your healthcare provider shows you the right way to use it. Epinephrine injection contains epinephrine, a medicine used to treat allergic emergencies (anaphylaxis). Clostridium spores can be present on the skin and introduced into the deep tissue with subcutaneous or intramuscular injection. Each 0.3 mL in epinephrine injection, USP 0.3 mg contains 0.3 mg epinephrine, 2.6 mg sodium chloride, not more than 1.5 mg chlorobutanol, 0.45 mg sodium bisulfite, hydrochloric acid and sodium hydroxide to adjust pH, and water for injection. Always keep your epinephrine injection in the carrying case to protect it from damage. Always carry your epinephrine injection with you because you may not know when anaphylaxis may happen. Epinephrine and other catecholamines have been shown to have mutagenic potential in vitro. Epinephrine is the first-line medication of choice for the treatment of anaphylaxis during pregnancy in humans. There are no available human data on the use of epinephrine injection in pregnant women to inform a drug-associated risk of adverse developmental outcomes. Disease-associated maternal and embryo/fetal risk: During pregnancy, anaphylaxis can be catastrophic and can lead to hypoxic-ischemic encephalopathy and permanent central nervous system damage or death in the mother and, more commonly, in the fetus or neonate. The prevalence of anaphylaxis occurring during pregnancy is reported to be approximately 3 cases per 100,000 deliveries. Reactions from Accidental Injection and/or Improper Technique, Cardiac Glycosides, Diuretics, and Anti-arrhythmics. Instruct patients that epinephrine injection, USP auto-injector must be properly disposed of once the blue caps have been removed or after use [see How Supplied/Storage and Handling (16)]. Use epinephrine injection exactly as your healthcare provider tells you to use it. DailyMed will deliver this notification to your desktop, Web browser, or e-mail depending on the RSS Reader you select to use. It should be clear and colorless. The symbol plus bar on the left side (pre) shows the pretreatment value for comparison with the baseline (Time 0) value. Accidental injection into the digits, hands or feet may result in loss of blood flow to the affected area. Epinephrine Injection, USP is administered by intravenous injection and/or in cardiac arrest, by intracardiac injection into the left ventricular chamber or via endotracheal tube directly into the bronchial tree. Intracardiaque : seulement dans le cas de gravité extrême, et la voie intraveineuse n’est pas viable On doit réaliser les deux derniers types d’administrationà l’hôpital, sous surveillance cardiaque et en diluant d’abord la solution … Replace epinephrine injection, USP auto-injector if the epinephrine solution appears discolored (pinkish or brown), cloudy, or contains particles. Premature ventricular contractions may appear within one minute after injection and may be followed by multifocal ventricular tachycardia (prefibrillation rhythm). Epinephrine injection should only be injected into the middle of the outer thigh (upper leg). The correct dose has been administered if you see the needle sticking out of the. The larger portion of injected doses is excreted in the urine as inactivated compounds and … What are the possible side effects of epinephrine injection? Throw away (dispose of) expired, unwanted, or unused epinephrine injections in an FDA-cleared sharps disposal container. You may be unable to speak in an allergic emergency. Keep epinephrine injection and all medicines out of the reach of children. To report SUSPECTED ADVERSE REACTIONS, contact Amneal Pharmaceuticals at 1-877-835-5472 or FDA at 1-800-FDA-1088 or, [see Indications and Usage (1), Dosage and Administration (2), [see Warnings and Precautions (5.5) and Overdosage (10)], [see Use in Specific Populations (8.1, 8.2)], [see How Supplied/Storage and Handling (16)]. Biochemical Data Summary. 1 mg every 3–5 minutes as required, a 1 in 10 000 (100 micrograms/mL) solution is recommended. Get emergency medical help right away. Cuts on the skin, bent needles, and needles that remain in the skin after the injection, have happened in young children who do not cooperate and kick or move during an injection. Carefully instruct patients who are at risk of or with a history of severe allergic reactions (anaphylaxis) to insect stings or bites, foods, drugs, and other allergens, as well as idiopathic and exercise-induced anaphylaxis, about the circumstances under which epinephrine should be used.
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